Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 6/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010135 | 0.89 | CCNT1 (0.53) | CDK9CCNT1JAK1KITTBK1 | |
| SCHEMBL14500417 | 0.89 | CDK9 (0.59) | CDK9CCNT1JAK1TBK1 | |
| SCHEMBL5008424 | 0.88 | BTK (0.43) | CDK9CCNT1BTKRET | |
| SCHEMBL5001675 | 0.85 | CCNT1 (0.49) | CDK9CCNT1JAK1KITTBK1 | |
| SCHEMBL13994061 | 0.84 | CCNT1 (0.55) | CDK9CCNT1KITTBK1GRM5 | |
| SCHEMBL5008291 | 0.83 | CCNT1 (0.51) | CDK9CCNT1KITTBK1BTK | |
| SCHEMBL5008373 | 0.82 | CCNT1 (0.48) | CDK9CCNT1JAK1KITTBK1 | |
| SCHEMBL5010250 | 0.82 | KIT (0.53) | CDK9CCNT1JAK1KITTBK1 | |
| SCHEMBL13994074 | 0.82 | CCNT1 (0.51) | CDK9CCNT1KITTBK1BTK | |
| SCHEMBL13994128 | 0.82 | CCNT1 (0.51) | CDK9CCNT1KITTBK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |