Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 11/20 | 0.53 |
| ▸ | CDK9 | P50750 | 11/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5001793 | 0.99 | CCNT1 (0.55) | CCNT1CDK9KITTBK1JAK1 | |
| SCHEMBL5005001 | 0.83 | CCNT1 (0.58) | CCNT1CDK9KITTBK1JAK1 | |
| SCHEMBL13994061 | 0.78 | CCNT1 (0.55) | CCNT1CDK9KITTBK1 | |
| SCHEMBL5665564 | 0.77 | CDK9 (0.66) | CCNT1CDK9TBK1 | |
| SCHEMBL16967833 | 0.77 | CDK9 (0.66) | CCNT1CDK9TBK1 | |
| SCHEMBL13994153 | 0.77 | CCNT1 (0.51) | CCNT1CDK9KITTBK1JAK1 | |
| SCHEMBL5010135 | 0.76 | CCNT1 (0.53) | CCNT1CDK9KITTBK1JAK1 | |
| SCHEMBL5008380 | 0.76 | CCNT1 (0.53) | CCNT1CDK9KITTBK1BTK | |
| SCHEMBL5004983 | 0.76 | CDK9 (0.51) | CCNT1CDK9KITTBK1JAK1 | |
| SCHEMBL14646826 | 0.75 | CCNT1 (0.62) | CCNT1CDK9BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |