Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13995352 | 0.91 | NR1H2 (0.48) | KIF11PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL13995370 | 0.88 | PTGDR2 (0.42) | NR1H2NR1H3S1PR1PTGDR2CA2 | |
| SCHEMBL12875596 | 0.85 | KIF11 (0.49) | KIF11PTGS2NR1H2NR1H3PTGDR2 | |
| SCHEMBL12406512 | 0.81 | S1PR1 (0.48) | S1PR1CA2ALOX5 | |
| SCHEMBL1190580 | 0.81 | KIF11 (0.47) | KIF11PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL3710331 | 0.80 | KIF11 (0.46) | KIF11PTGS2NR1H2NR1H3PTGDR2 | |
| SCHEMBL1191536 | 0.80 | KIF11 (0.46) | KIF11PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL31716134 | 0.80 | KIF11 (0.46) | KIF11PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL13995361 | 0.78 | PTGDR2 (0.43) | NR1H2NR1H3PTGDR2BRD4 | |
| SCHEMBL13995384 | 0.77 | KIF11 (0.44) | KIF11PTGS2PTGS1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312229-A1 | Organic Compounds | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312229-A1 | Organic Compounds | DRD4, DRD1, SLC10A6 | KIF11 2496/4885PTGS2 2670/4885PTGS1 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.