Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037628 | 0.90 | CHEK1 (0.46) | KDM4ECCNT1CDK9MEN1MAPT | |
| SCHEMBL5164330 | 0.86 | CHEK1 (0.43) | CCNT1CDK9MEN1MAPTKMT2A | |
| SCHEMBL2036334 | 0.85 | CHEK1 (0.47) | KDM4ECCNT1CDK9MEN1MAPT | |
| SCHEMBL13997115 | 0.84 | CHEK1 (0.48) | HCRTR1KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL2031898 | 0.83 | CDK9 (0.50) | CCNT1CDK9CHEK1FECHKCNH2 | |
| SCHEMBL2036175 | 0.83 | MAP3K5 (0.39) | HCRTR1KDM4ECCNT1CDK9MEN1 | |
| Hydrochloric Acid SCHEMBL5059305 | 0.83 | CHEK1 (0.47) | HCRTR1KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL2034857 | 0.80 | KDM4E (0.47) | KDM4EMEN1MAPTKMT2ALMNA | |
| SCHEMBL5165393 | 0.80 | CHEK1 (0.43) | CCNT1CDK9CHEK1FECHKCNH2 | |
| SCHEMBL27644607 | 0.79 | CHEK1 (0.44) | CCNT1CDK9CHEK1FECHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | claimed |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| CN-101115727-A | Compounds for inhibition of CHK1 | ICOS CORP (US) | 2008-01-30 | — | — | CN | disclosed |
| EP-1778648-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006021002-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | CHEK1, PCNA, CHEK2 | HCRTR1 4805/4885KDM4E 2395/4885CCNT1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.