Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606604 | 1.00 | EPHX1 (0.38) | EPHX1JAK2JAK1CNR2PDGFRB | |
| SCHEMBL1606607 | 1.00 | EPHX1 (0.38) | EPHX1JAK2JAK1CNR2PDGFRB | |
| SCHEMBL13998352 | 0.99 | EPHX1 (0.35) | EPHX1JAK2JAK1CNR2PDGFRB | |
| SCHEMBL1605100 | 0.99 | EPHX1 (0.35) | EPHX1JAK2JAK1CNR2PDGFRB | |
| SCHEMBL1605101 | 0.99 | EPHX1 (0.35) | EPHX1JAK2JAK1CNR2PDGFRB | |
| SCHEMBL1605672 | 0.87 | ALDH1A1 (0.35) | JAK2JAK1CNR2ALDH1A1 | |
| SCHEMBL1605674 | 0.87 | ALDH1A1 (0.35) | JAK2JAK1CNR2ALDH1A1 | |
| SCHEMBL13998624 | 0.87 | ALDH1A1 (0.35) | JAK2JAK1CNR2ALDH1A1 | |
| SCHEMBL13998475 | 0.82 | ALDH1A1 (0.34) | JAK2JAK1CNR2ALDH1A1JAK3 | |
| SCHEMBL13998501 | 0.82 | ALDH1A1 (0.34) | JAK2JAK1CNR2ALDH1A1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |
| US-7253196-B2 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 | AMGEN, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| WO-2007061661-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |