Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 9/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.50 |
| ▸ | GSK3B | P49841 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998471 | 0.90 | GSK3B (0.48) | MAPTMEN1KMT2ACDK2CCNE1 | |
| SCHEMBL13998513 | 0.85 | GSK3B (0.59) | CDK2CCNE1GSK3B | |
| SCHEMBL12952864 | 0.84 | CDK2 (0.73) | CDK2CCNE1GSK3B | |
| SCHEMBL13998482 | 0.83 | GSK3B (0.68) | CDK2CCNE1GSK3B | |
| SCHEMBL12952889 | 0.79 | CDK2 (0.69) | CDK2CCNE1GSK3B | |
| SCHEMBL13998487 | 0.79 | GSK3B (0.52) | CDK2CCNE1GSK3B | |
| SCHEMBL13998463 | 0.78 | GSK3B (0.52) | CDK2CCNE1GSK3B | |
| SCHEMBL13998528 | 0.78 | GSK3B (0.62) | CDK2CCNE1GSK3B | |
| SCHEMBL12953753 | 0.78 | KDM4E (0.48) | MAPTMEN1KMT2ACDK2GSK3B | |
| SCHEMBL14547287 | 0.77 | GSK3B (0.45) | CDK2CCNE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |