Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998622 | 0.93 | GSK3B (0.48) | GSK3BCYP2D6CYP2C9GRIN2BCYP3A4 | |
| SCHEMBL13998618 | 0.92 | GSK3B (0.54) | GSK3BCYP2D6CYP2C9GRIN2BCYP3A4 | |
| SCHEMBL12954179 | 0.90 | GSK3B (0.67) | GSK3BCCNE1CDK2 | |
| SCHEMBL11931133 | 0.87 | GSK3B (0.49) | GSK3BCYP2D6CYP2C9GRIN2BCYP3A4 | |
| SCHEMBL13885057 | 0.86 | GSK3B (0.49) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL13885699 | 0.85 | GSK3B (0.43) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL13998619 | 0.84 | GRIN2B (0.52) | GSK3BCYP2D6CYP2C9GRIN2BCYP3A4 | |
| SCHEMBL12953232 | 0.84 | TRPC3 (0.44) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL14528946 | 0.83 | GSK3B (0.41) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL12953255 | 0.82 | CHEK1 (0.48) | GSK3BJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |