Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.37 |
| ▸ | BCL9 | O00512 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | F13A1 | P00488 | 3/20 | 0.37 |
| ▸ | TGM2 | P21980 | 3/20 | 0.37 |
| ▸ | TGM1 | P22735 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885057 | 0.91 | GSK3B (0.49) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL13885699 | 0.90 | GSK3B (0.43) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL13998622 | 0.87 | GSK3B (0.48) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL13885055 | 0.83 | GSK3B (0.51) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL13998621 | 0.83 | GSK3B (0.52) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL12954179 | 0.79 | GSK3B (0.67) | GSK3BCDK2 | |
| SCHEMBL12953558 | 0.79 | GSK3B (0.50) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL12953762 | 0.78 | GSK3B (0.51) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL13998619 | 0.78 | GRIN2B (0.52) | GSK3BCDK2JAK2JAK1TYK2 | |
| SCHEMBL12953255 | 0.78 | CHEK1 (0.48) | GSK3BCDK2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |