SCHEMBL14003809

SCHEMBL14003809

O=Cc1ccc(N(C=C(c2ccccc2)c2ccccc2)c2ccc(/C=C/C=C/C=C/c3ccccc3)c3ccccc23)cc1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.32
LMNA P02545 2/20 0.31
ALDH1A1 P00352 2/20 0.31
TRPA1 O75762 1/20 0.31
ALOX5 P09917 1/20 0.31
MAPK1 P28482 1/20 0.31
MAOB P27338 1/20 0.30
CYP2A6 P11509 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14003806 0.99 KMT2A (0.32) KMT2ALMNAALDH1A1TRPA1ALOX5
SCHEMBL9972131 0.93 MAOB (0.35) LMNAMAOB
SCHEMBL20109432 0.90 APP (0.34) MAOB
SCHEMBL13587096 0.87 ALDH1A1 (0.33) ALDH1A1CYP2A6
SCHEMBL14028743 0.87 MAOB (0.30) MAOB
SCHEMBL13990770 0.87 ALDH1A1 (0.35) KMT2ALMNAALDH1A1ALOX5MAPK1
SCHEMBL12549940 0.87 ALDH1A1 (0.35) KMT2ALMNAALDH1A1ALOX5MAPK1
SCHEMBL14081233 0.86 APP (0.39) KMT2ALMNAALDH1A1TRPA1MAPK1
SCHEMBL14081210 0.86 MAOB (0.39) LMNAALDH1A1TRPA1ALOX5MAPK1
SCHEMBL9972134 0.86 MAOB (0.31) MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7449269-B2 Electrophotographic photoreceptor having defined mobility of electric charges in photosensitive layer and image forming device incorporating same SHARP KABUSHIKI KAISHA (JP) 2008-11-11 US disclosed