Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.35 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.35 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005428 | 0.85 | AKT1 (0.42) | AKT1RPS6KB1RPS6KA5PRKG2PRKG1 | |
| SCHEMBL14030189 | 0.82 | AKT1 (0.41) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14005445 | 0.81 | LMNA (0.38) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14005442 | 0.80 | AKT1 (0.45) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14005444 | 0.79 | AKT1 (0.37) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14005424 | 0.78 | AKT1 (0.41) | AKT1PRKACA | |
| SCHEMBL14004847 | 0.78 | AKT1 (0.42) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14004852 | 0.78 | AKT1 (0.42) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14005638 | 0.78 | AKT1 (0.42) | AKT1PIM1RPS6KB1GSK3AGSK3B | |
| SCHEMBL14004833 | 0.77 | AKT1 (0.57) | AKT1PIM1RPS6KB1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | AKT1 157/4885PIM1 184/4885RPS6KB1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.