Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.54 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PRKX | P51817 | 2/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27822275 | 0.87 | KDM4E (0.56) | MAPK1HPGDHSD17B10ALDH1A1KDM4E | |
| SCHEMBL2466551 | 0.86 | MAPK1 (0.52) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7787024 | 0.84 | BACE1 (0.58) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7383027 | 0.84 | MAPK1 (0.55) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7381726 | 0.84 | BACE1 (0.58) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7782099 | 0.84 | MAPK1 (0.55) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7787779 | 0.82 | CAPN1 (0.65) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7789809 | 0.82 | CAPN1 (0.65) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7372187 | 0.82 | CAPN1 (0.65) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 | |
| SCHEMBL7372990 | 0.82 | CAPN1 (0.65) | MAPK1CYP3A4ROCK2ROCK1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | AMERICAN DIAGNOSTICA INC. | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | SERPINE1, SERPINC1, SERPINB1 | MAPK1 1678/4885CYP3A4 2560/4885ROCK2 4035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.