Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67071 | 0.94 | RXRA (0.42) | S1PR1RXRAS1PR5TRPV1CYP3A4 | |
| SCHEMBL69551 | 0.93 | TRPV1 (0.36) | TRPV1CYP3A4CYP2C8CYP2C9CYP2B6 | |
| SCHEMBL67083 | 0.88 | PPARG (0.43) | S1PR1RXRAS1PR5TRPV1HPGD | |
| SCHEMBL70090 | 0.87 | PPARG (0.39) | TRPV1CYP3A4CYP2C8CYP2C9CYP2B6 | |
| SCHEMBL68746 | 0.84 | MMP2 (0.40) | S1PR1RXRAFFAR4HPGD | |
| SCHEMBL1400940 | 0.82 | S1PR1 (0.40) | S1PR1RXRAS1PR5CYP3A4CYP2C8 | |
| SCHEMBL68467 | 0.79 | RXRA (0.41) | S1PR1RXRATRPV1CYP3A4CYP2C8 | |
| SCHEMBL69550 | 0.75 | CYP3A4 (0.37) | CYP3A4CYP2C8CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL67800 | 0.75 | CYP4F2 (0.39) | TRPV1HPGD | |
| SCHEMBL67070 | 0.75 | RXRA (0.44) | S1PR1RXRAS1PR5CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814871-B1 | COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RES & DEV (FR) | 2011-03-02 | — | — | EP | claimed |