Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TYMP | P19971 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986957 | 0.90 | POLB (0.66) | POLBENPP1P2RY1HIF1ANT5E | |
| SCHEMBL6513690 | 0.86 | ADORA3 (0.61) | POLBENPP1P2RY1HIF1A | |
| Deoxyinosine SCHEMBL1401252 | 0.86 | HIF1A (0.66) | HIF1APNPLMNATP53HTT | |
| SCHEMBL11418879 | 0.85 | HIF1A (0.52) | POLBENPP1P2RY1HIF1ATYMP | |
| SCHEMBL444962 | 0.85 | HIF1A (0.58) | POLBENPP1P2RY1HIF1ATYMP | |
| SCHEMBL1533828 | 0.84 | POLB (0.65) | POLBENPP1P2RY1HIF1ANT5E | |
| SCHEMBL1533826 | 0.84 | POLB (0.65) | POLBENPP1P2RY1HIF1ANT5E | |
| SCHEMBL9345725 | 0.83 | HIF1A (0.58) | POLBENPP1P2RY1HIF1APNP | |
| SCHEMBL6839710 | 0.83 | HIF1A (0.58) | POLBENPP1P2RY1HIF1A | |
| SCHEMBL9345705 | 0.83 | HIF1A (0.58) | POLBENPP1P2RY1HIF1APNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970717-B2 | Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands | CEPHEID (US) | 2024-04-30 | — | — | US | disclosed |
| US-11840728-B2 | Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands | CEPHEID (US) | 2023-12-12 | — | — | US | disclosed |
| CN-115702243-A | Guanosine analogs for therapeutic polynucleotides | 罗氏创新中心哥本哈根有限公司 | 2023-02-14 | — | — | CN | disclosed |
| US-20220251525-A1 | INHIBITION OF NUCLEIC ACID POLYMERASES BY ENDONUCLEASE V-CLEAVABLE CIRCULAR OLIGONUCLEOTIDE LIGANDS | CEPHEID | 2022-08-11 | — | — | US | disclosed |
| US-20220119861-A1 | INHIBITION OF NUCLEIC ACID POLYMERASES BY ENDONUCLEASE V-CLEAVABLE OLIGONUCLEOTIDE LIGANDS | CEPHEID | 2022-04-21 | — | — | US | disclosed |
| US-11299719-B2 | Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands | CEPHEID (US) | 2022-04-12 | — | — | US | disclosed |
| US-11155859-B2 | Inhibition of nucleic acid polymerases by endonuclease v-cleavable oligonucleotide ligands | CEPHEID (US) | 2021-10-26 | — | — | US | disclosed |
| CN-107148424-B | Cyclic dinucleotides for inducing cytokines | 凯拉治疗股份公司 | 2021-01-08 | — | — | CN | disclosed |
| US-20200392561-A1 | INHIBITION OF NUCLEIC ACID POLYMERASES BY ENDONUCLEASE V-CLEAVABLE OLIGONUCLEOTIDE LIGANDS | CEPHEID | 2020-12-17 | — | — | US | disclosed |
| US-20200377869-A1 | INHIBITION OF NUCLEIC ACID POLYMERASES BY ENDONUCLEASE V-CLEAVABLE CIRCULAR OLIGONUCLEOTIDE LIGANDS | CEPHEID | 2020-12-03 | — | — | US | disclosed |
| WO-2002026757-A2 | MODULATION OF IMMUNOSTIMULATORY ACTIVITY OF IMMUNOSTIMULATORY OLIGONUCLEOTIDE ANALOGS BY POSITIONAL CHEMICAL CHANGES | HYBRIDON, INC. (US) | 2002-04-04 | — | — | WO | disclosed |
| WO-2001083503-A2 | MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES | HYBRIDON, INC. (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-0806966-A1 | CATIONIC COPOLYMERS OF VINYLAMINE AND VINYL ALCOHOL FOR THE DELIVERY OF OLIGONUCLEOTIDES | AMGEN INC. (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5629184-A | TO CELL CYTOPLASM, ANTISENSE THERAPY | AMGEN INC. (US) | 1997-05-13 | — | — | US | disclosed |
| WO-1996022792-A1 | CATIONIC COPOLYMERS OF VINYLAMINE AND VINYL ALCOHOL FOR THE DELIVERY OF OLIGONUCLEOTIDES | AMGEN INC. (US) | 1996-08-01 | — | — | WO | disclosed |
| WO-1996011266-A2 | METHOD FOR INHIBITING SMOOTH MUSCLE CELL PROLIFERATION AND OLIGONUCLEOTIDES FOR USE THEREIN | AMGEN INC. (US) | 1996-04-18 | — | — | WO | disclosed |
| EP-0439550-A4 | DNA SEQUENCING BY MULTIPLE MIXED OLIGONUCLEOTIDE PROBES | — | 1991-09-25 | — | — | EP | disclosed |
| EP-0439550-A1 | DNA SEQUENCING BY MULTIPLE MIXED OLIGONUCLEOTIDE PROBES | DNAX RESEARCH INSTITUTE OF MOLECULAR AND CELLULAR BIOLOGY, INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-5002867-A | Nucleic acid sequence determination by multiple mixed oligonucleotide probes | CALLIDA GENOMICS, INC. | 1991-03-26 | — | — | US | disclosed |
| WO-1990004652-A1 | DNA SEQUENCING BY MULTIPLE MIXED OLIGONUCLEOTIDE PROBES | DNAX RESEARCH INSTITUTE OF MOLECULAR AND CELLULAR BIOLOGY, INC. (US) | 1990-05-03 | — | — | WO | disclosed |