Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.82 |
| ▸ | HPGD | P15428 | 6/20 | 0.82 |
| ▸ | TSHR | P16473 | 5/20 | 0.82 |
| ▸ | CASP1 | P29466 | 4/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.82 |
| ▸ | CASP7 | P55210 | 3/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13723869 | 0.89 | ALDH1A1 (0.82) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3283135 | 0.88 | KDM4E (0.84) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL13749385 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL15760566 | 0.87 | KDM4E (0.78) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL14013782 | 0.87 | ALDH1A1 (0.79) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL4203990 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL4088135 | 0.82 | HSD17B10 (0.78) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL9301152 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL1008095 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL4204293 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |