Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 9/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | CASP1 | P29466 | 5/20 | 1.00 |
| ▸ | CASP7 | P55210 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | KLK7 | P49862 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731467 | 0.92 | MAPT (0.85) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL13731195 | 0.91 | MAPT (0.83) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL13731982 | 0.90 | MAPT (1.00) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL14014115 | 0.89 | MAPT (0.80) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL14014111 | 0.88 | KDM4E (1.00) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL14014110 | 0.85 | KDM4E (1.00) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL3283135 | 0.85 | KDM4E (0.84) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL2459588 | 0.84 | KDM4E (0.81) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL15760566 | 0.84 | KDM4E (0.78) | KDM4EHSD17B10HPGDTSHRCASP1 | |
| SCHEMBL13888945 | 0.84 | KDM4E (0.76) | KDM4EHSD17B10HPGDTSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572113-B1 | CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2017-05-17 | — | — | EP | disclosed |
| US-9447100-B2 | Substituted pyrazolo[1,5-A] pyrimidines as calcium receptor modulating agents | TAKEDA PHARMACEUTICAL COMPANY, LTD. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20140155416-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-06-05 | — | — | US | disclosed |
| US-20090215746-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS | TAKEDA PHARMACEUTICALS COMPANY LIMITED (JP) | 2009-08-27 | — | — | US | disclosed |
| US-20090215746-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS | TAKEDA PHARMACEUTICALS COMPANY LIMITED (JP) | 2009-08-27 | — | — | US | disclosed |
| US-7514441-B2 | Substituted pyrazolo [1,5-A]pyrimidines as calcium receptor modulating agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-07 | — | — | US | disclosed |
| US-7514441-B2 | Substituted pyrazolo [1,5-A]pyrimidines as calcium receptor modulating agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215746-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS | CASR, NR2C2, RYR1 | KDM4E 2686/4885HSD17B10 2820/4885HPGD 2279/4885 |
| US-20140155416-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS | CASR, NR2C2, RYR1 | KDM4E 2686/4885HSD17B10 2820/4885HPGD 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.