Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15840485 | 0.77 | DRD2 (0.54) | MEN1KMT2ACHRM4DRD2HTR2C | |
| SCHEMBL4813515 | 0.77 | CHRM4 (0.58) | MEN1KMT2ACHRM4DRD2HTR2C | |
| SCHEMBL17208434 | 0.76 | DRD2 (0.55) | MEN1KMT2ACHRM4DRD2HTR2C | |
| SCHEMBL1581482 | 0.74 | DRD2 (0.58) | CHRM4DRD2HTR2CCCR2GRM2 | |
| SCHEMBL1761033 | 0.73 | DRD2 (0.56) | CHRM4DRD2HTR2CCCR2DRD4 | |
| SCHEMBL5755275 | 0.72 | KDM4E (0.50) | MEN1KMT2ACHRM4DRD2NPSR1 | |
| Hydrochloric Acid SCHEMBL4810213 | 0.72 | KDM4E (0.49) | MEN1KMT2ACHRM4DRD2NPSR1 | |
| SCHEMBL22605456 | 0.72 | ECE2 (0.48) | ECE2 | |
| SCHEMBL29518257 | 0.72 | ECE2 (0.48) | ECE2 | |
| SCHEMBL20349607 | 0.70 | KMT2A (1.00) | MEN1KMT2ACNR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383761-B1 | Phenyl- and pyridyl-piperidines with tnf activity | SANOFI AVENTIS (FR) | 2011-03-02 | — | — | EP | disclosed |
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | SANOFI-AVENTIS (FR) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | TNF, TNFRSF1A, NGFR | ECE2 2285/4885MEN1 4617/4885KMT2A 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.