Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MARS1 | P56192 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.44 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014210 | 0.89 | MARS1 (0.63) | KDM4EALDH1A1MARS1MAPTLMNA | |
| SCHEMBL14014206 | 0.89 | KDM4E (0.59) | KDM4EALDH1A1MARS1MAPTTP53 | |
| SCHEMBL14014246 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1MAPTLMNATP53 | |
| SCHEMBL14014191 | 0.88 | KDM4E (0.62) | KDM4EALDH1A1MAPTLMNATP53 | |
| SCHEMBL14014202 | 0.87 | ALDH1A1 (0.69) | KDM4EALDH1A1MARS1MAPTTP53 | |
| SCHEMBL14014295 | 0.86 | BACE1 (0.58) | KDM4EALDH1A1MARS1CYP2C9HPGD | |
| SCHEMBL14014203 | 0.85 | KDM4E (0.55) | KDM4EALDH1A1MARS1MAPTTP53 | |
| SCHEMBL14014212 | 0.85 | ALDH1A1 (0.66) | KDM4EALDH1A1MARS1MAPTTP53 | |
| SCHEMBL14014254 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1MAPTLMNATP53 | |
| SCHEMBL14014211 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1MARS1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |