Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708050 | 0.92 | KDM4E (0.52) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL4706821 | 0.92 | KDM4E (0.52) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL14014460 | 0.90 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL4706807 | 0.87 | KDM4E (0.47) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL14014391 | 0.86 | GRM2 (0.48) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL4709978 | 0.86 | GRM2 (0.48) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL14013953 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL14014373 | 0.83 | SMN1; SMN2 (0.65) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL4707789 | 0.82 | SMN1; SMN2 (0.49) | KDM4EALDH1A1HPGDCLK4RXFP1 | |
| SCHEMBL4707687 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1HPGDCLK4RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |