Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.47 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015043 | 0.91 | NSD2 (0.46) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14542088 | 0.91 | NSD2 (0.38) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14015035 | 0.91 | ALDH1A1 (0.43) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL4707770 | 0.89 | DHODH (0.41) | DHODHPLAT | |
| SCHEMBL14015087 | 0.89 | PLAT (0.43) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14015048 | 0.88 | NSD2 (0.43) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14257367 | 0.87 | PLAT (0.39) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14015051 | 0.86 | PLAT (0.40) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14015088 | 0.85 | PIK3CA (0.39) | NSD2NSD1NSD3LPAR5HPSE | |
| SCHEMBL14015091 | 0.85 | LMNA (0.39) | NSD2NSD1NSD3LPAR5HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |