Phosphoric Acid

Phosphoric Acid

SCHEMBL1401729

O=C([O-])[O-].O=C([O-])[O-].O=C([O-])[O-].O=P(O)(O)O.O=P(O)(O)O.[La+3].[La+3]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
SLC34A1 Q06495 1/20 0.43
CA4 P22748 4/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 1/20 0.36
FAHD1 Q6P587 1/20 0.36
PEPD P12955 1/20 0.32
BLM P54132 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
KDM4E B2RXH2 2/20 0.31
MMP2 P08253 2/20 0.31
THRB P10828 1/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31
FDPS P14324 1/20 0.31
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL29145675 1.00 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL1401797 0.96 LMNA (0.44) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL28272622 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL28145512 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL28133941 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL6321642 0.91
Phosphoric Acid SCHEMBL7083907 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL5610258 0.91 SLC34A1 (0.54) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL15270770 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2
Phosphoric Acid SCHEMBL28108693 0.91 LMNA (0.47) LMNASLC34A1CA4CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389102-B1 USE OF LANTHANUM CARBONATE FOR THE PREVENTION OF KIDNEY STONE DISEASE SHIRE INT LICENSING BV (NL) 2011-03-02 EP disclosed
US-20070116782-A1 USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE SHIRE INTERNATIONAL LICENSING B.V. (NL) 2007-05-24 US disclosed
US-7192609-B2 Use of rare earth compounds for the prevention of kidney stone disease SHIRE INTERNATIONAL LICENSING B.V. (NL) 2007-03-20 US disclosed
EP-1389102-A4 USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE ANORMED INC (CA) 2004-07-14 EP disclosed
EP-1389102-A1 USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE ANORMED INC. (CA) 2004-02-18 EP disclosed
WO-2002085348-A1 USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE ANORMED INC. (CA) 2002-10-31 WO disclosed
US-20020155168-A1 Use of rare earth compounds for the prevention of kidney stone disease SHIRE INTERNATIONAL LICENSING B.V. (NL) 2002-10-24 US disclosed