Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL72939 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL153476 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL150638 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL28576576 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL22476039 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL150902 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3237788 | 0.94 | — | — | |
| Bicarbonate SCHEMBL14563499 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL40504 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL14563712 | 0.89 | CA4 (0.39) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389102-B1 | USE OF LANTHANUM CARBONATE FOR THE PREVENTION OF KIDNEY STONE DISEASE | SHIRE INT LICENSING BV (NL) | 2011-03-02 | — | — | EP | disclosed |
| US-20070116782-A1 | USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-05-24 | — | — | US | disclosed |
| US-7192609-B2 | Use of rare earth compounds for the prevention of kidney stone disease | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-03-20 | — | — | US | disclosed |
| EP-1389102-A4 | USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE | ANORMED INC (CA) | 2004-07-14 | — | — | EP | disclosed |
| EP-1389102-A1 | USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE | ANORMED INC. (CA) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002085348-A1 | USE OF RARE EARTH COMPOUNDS FOR THE PREVENTION OF KIDNEY STONE DISEASE | ANORMED INC. (CA) | 2002-10-31 | — | — | WO | disclosed |
| US-20020155168-A1 | Use of rare earth compounds for the prevention of kidney stone disease | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2002-10-24 | — | — | US | disclosed |
| US-6362375-B1 | RARE EARTH TRIFLUOROMETHYLSULFONE FRIEDAL-CRAFTS CATALYZED REACTION BETWEEN A CARBOXYLIC ACID AMD AN AROMATIC COMPOUND | COLLEGE OF THE HOLY CROSS | 2002-03-26 | — | — | US | disclosed |
| US-6017442-A | Hydrocarbon conversion with dual metal promoted zeolite | PHILLIPS PETROLEUM COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| US-5045289-A | Separation method, carbonates are removed by solvent extraction or ion exchanging | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| WO-1991004945-A1 | FORMATION OF RARE EARTH CARBONATES USING SUPERCRITICAL CARBON DIOXIDE | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1991-04-18 | — | — | WO | disclosed |