Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL153476 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL150638 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL28576576 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL1401747 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL22476039 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL150902 | 1.00 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3237788 | 0.94 | — | — | |
| Bicarbonate SCHEMBL14563499 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL40504 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL14563712 | 0.89 | CA4 (0.39) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119709198-A | Eu3+/Mn4+Co-doped luminescent material, and preparation method and application thereof | 安徽三联学院 | 2025-03-28 | — | — | CN | claimed |
| CN-119120018-A | Mn (Mn)4+Doped deep red light luminescent material, and preparation method and application thereof | 安徽三联学院 | 2024-12-13 | — | — | CN | claimed |
| US-12145131-B2 | Polymeric lanthanum nanocomposite, and preparation method and application thereof | NANJING UNIVERSITY (CN) | 2024-11-19 | — | — | US | claimed |
| CN-117947461-A | Preparation method, structure and application of non-noble metal oxide modified ultra-fine noble metal nano particles synthesized by low-temperature heat treatment | 大连理工大学 | 2024-04-30 | — | — | CN | claimed |
| CN-112442367-B | LED fluorescent powder capable of changing color along with temperature and preparation method and application thereof | 南京邮电大学 | 2022-09-06 | — | — | CN | claimed |
| US-20220219142-A1 | POLYMERIC LANTHANUM NANOCOMPOSITE, AND PREPARATION METHOD AND APPLICATION THEREOF | NANJING UNIVERSITY (CN) | 2022-07-14 | — | — | US | claimed |
| CN-114653356-A | Preparation method of lanthanum-doped cerium dioxide catalyst material and formaldehyde-removing compound | 江汉大学 | 2022-06-24 | — | — | CN | claimed |
| CN-114524452-A | Nano lanthanum carbonate hydrate and preparation method and application thereof | 浙江大学 | 2022-05-24 | — | — | CN | claimed |
| CN-110681368-B | Resin-based nano lanthanum material, preparation method and application | 南京大学 | 2021-10-26 | — | — | CN | claimed |
| CN-110664769-B | Lanthanum carbonate orally disintegrating tablet and preparation method thereof | 常州市阳光药业有限公司 | 2021-10-15 | — | — | CN | claimed |
| WO-2010131255-A1 | PROCESS FOR THE PREPARATION OF LANTHANUM CARBONATE DIHYDRATE | NATCO PHARMA LIMITED (IN) | 2010-11-18 | — | — | WO | claimed |
| WO-2010085520-A1 | DISINTEGRABLE FORMULATIONS OF LANTHANUM CARBONATE | MYLAN INC. (US) | 2010-07-29 | — | — | WO | claimed |
| US-20100015246-A1 | COMBINATION OF A LANTHANUM COMPOUND AND BONE ENHANCING AGENT FOR THE TREATMENT OF BONE DISEASES | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2010-01-21 | — | — | US | claimed |
| EP-1294384-B1 | USE OF LANTHANUM COMPOUNDS FOR THE TREATMENT OF BONE DISEASES | SHIRE HOLDINGS AG (CH) | 2009-03-11 | — | — | EP | claimed |
| WO-2007056721-A2 | TREATMENT OF CHRONIC KIDNEY DISEASE (CKD) SUBJECTS USING LANTHANUM COMPOUNDS | SHIRE INTERNATIONAL LICENSING B.V (NL) | 2007-05-18 | — | — | WO | claimed |
| EP-1785142-A1 | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds | Shire International Licensing B.V. (NL) | 2007-05-16 | — | — | EP | claimed |
| US-20070104799-A1 | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-05-10 | — | — | US | claimed |
| US-7192609-B2 | Use of rare earth compounds for the prevention of kidney stone disease | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-03-20 | — | — | US | claimed |
| US-20070048390-A1 | Combination of a lanthanum compound and bone enhancing agent for the treatment of bone diseases | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-03-01 | — | — | US | claimed |
| US-7078059-B2 | Treatment of bone diseases | SHIRE HOLDINGS AG (CH) | 2006-07-18 | — | — | US | claimed |