Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167423 | 1.00 | MMP9 (0.48) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL21843955 | 1.00 | MMP9 (0.48) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL7750033 | 1.00 | MMP9 (0.48) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL20131094 | 1.00 | MMP9 (0.48) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL13039794 | 1.00 | MMP9 (0.48) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL20131063 | 0.84 | MMP9 (0.47) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL24946114 | 0.83 | MMP9 (0.43) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL18893525 | 0.82 | MMP9 (0.46) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL18893378 | 0.82 | MMP9 (0.46) | MMP9MMP1MMP2MMP8PSEN1 | |
| SCHEMBL12380788 | 0.81 | OPRM1 (0.41) | MMP9MMP1MMP2MMP8MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7173031-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | disclosed |
| CN-1197070-A | Process for preparing optically active phenylglycidyl acid derivative | DSM NV (NL) | 1998-10-28 | — | — | CN | disclosed |