Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP14 | P50281 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303623 | 0.81 | MMP13 (0.40) | TP53THRBPOLBMMP13MMP14 | |
| SCHEMBL8303855 | 0.80 | MMP13 (0.54) | TP53THRBMMP13MMP14CYP3A4 | |
| SCHEMBL3944032 | 0.79 | MMP13 (0.38) | TP53THRBPOLBMMP13MMP14 | |
| SCHEMBL3942288 | 0.79 | MMP13 (0.38) | TP53THRBPOLBMMP13MMP14 | |
| SCHEMBL3944035 | 0.79 | MMP13 (0.38) | TP53THRBPOLBMMP13MMP14 | |
| SCHEMBL8299383 | 0.78 | MMP13 (0.70) | TP53THRBMMP13MMP14CYP3A4 | |
| SCHEMBL3934693 | 0.77 | TP53 (0.46) | TP53THRBPOLBMEN1KMT2A | |
| SCHEMBL3936267 | 0.77 | POLB (0.50) | TP53POLBMEN1KMT2AMAPT | |
| SCHEMBL3934827 | 0.76 | MMP13 (0.39) | TP53THRBPOLBMMP13MMP14 | |
| SCHEMBL3935385 | 0.75 | TP53 (0.38) | TP53THRBPOLBMMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644340-B1 | N-[({'4-SUBSTITUTED PIPERAZINE-1-YL}SULFONYLMETHYL)ALKYL]-N-HYDROXYFORMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-11-12 | — | — | EP | disclosed |