Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | MMP14 | P50281 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923645 | 0.83 | MMP13 (0.57) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL14019092 | 0.81 | TP53 (0.42) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL3943167 | 0.76 | CYP3A4 (0.43) | MMP13MMP14CYP3A4MMP1POLB | |
| SCHEMBL5883255 | 0.76 | CYP3A4 (0.41) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL8304525 | 0.75 | CYP3A4 (0.46) | MMP13MMP14CYP3A4POLBMAPT | |
| SCHEMBL8299382 | 0.75 | MMP13 (0.58) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL3936734 | 0.72 | CYP3A4 (0.51) | MMP13CYP3A4MAPT | |
| SCHEMBL13923646 | 0.72 | MMP13 (0.57) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL3942288 | 0.72 | MMP13 (0.38) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL3944035 | 0.72 | MMP13 (0.38) | MMP13MMP14CYP3A4ADAMTS4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644340-B1 | N-[({'4-SUBSTITUTED PIPERAZINE-1-YL}SULFONYLMETHYL)ALKYL]-N-HYDROXYFORMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-11-12 | — | — | EP | disclosed |
| WO-2005000822-A1 | N-{‘4-SUBSTITUTED PIPERAZINE-1-SULFONYLMETHYL!ALKYL}-N-HYDROXYFOMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-06 | — | — | WO | disclosed |