Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 7/20 | 0.61 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424817 | 0.81 | METAP1 (0.65) | METAP1THRATHRBACHECYP19A1 | |
| SCHEMBL6280170 | 0.81 | METAP1 (0.72) | METAP1THRATHRBACHESIGMAR1 | |
| SCHEMBL18052663 | 0.80 | THRA (0.53) | METAP1THRATHRBCYP19A1 | |
| SCHEMBL1853465 | 0.80 | ACHE (0.63) | METAP1ACHECYP19A1HTR1AHTR2A | |
| SCHEMBL15617637 | 0.80 | METAP1 (0.66) | METAP1THRATHRBACHECYP19A1 | |
| SCHEMBL29130764 | 0.77 | METAP1 (0.64) | METAP1THRATHRBCYP19A1 | |
| SCHEMBL4858831 | 0.77 | THRA (0.58) | METAP1THRATHRBACHECYP19A1 | |
| SCHEMBL5343888 | 0.77 | BAZ2B (0.47) | THRATHRBHTR1AHTR2C | |
| SCHEMBL4856956 | 0.76 | THRA (0.41) | METAP1THRATHRBACHECYP19A1 | |
| SCHEMBL11803298 | 0.76 | SIRT2 (0.41) | METAP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432284-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2008-10-07 | — | — | US | disclosed |