Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | AHCY | P23526 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239127 | 1.00 | LMNA (0.41) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL1401951 | 1.00 | LMNA (0.41) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL12003121 | 1.00 | LMNA (0.41) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL8960068 | 1.00 | LMNA (0.41) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL3714471 | 1.00 | LMNA (0.41) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL242481 | 0.93 | LMNA (0.40) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL13177712 | 0.91 | HTR2C (0.38) | HTR2CHTR2BTMIGD3ADORA3ADORA1 | |
| SCHEMBL4352873 | 0.91 | LMNA (0.39) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL13211904 | 0.89 | LMNA (0.43) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL10158794 | 0.86 | ADORA3 (0.53) | ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018388-B9 | BISADENOSINE COMPOUNDS AS ADENOSINE A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| EP-2018388-B1 | BISADENOSINE COMPOUNDS AS ADENOSINE A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| EP-2292619-A1 | Purine derivatives for use as adenonsin A-2A receptor agonists | Novartis AG (CH) | 2011-03-09 | — | — | EP | disclosed |