Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 18/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020082 | 1.00 | KIF11 (0.47) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL14020854 | 0.88 | KIF11 (0.40) | KIF11KDM4E | |
| SCHEMBL14530269 | 0.84 | KIF11 (0.45) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL14019804 | 0.83 | KIF11 (0.46) | KIF11KDM4EMEN1GAAKMT2A | |
| SCHEMBL14529871 | 0.82 | KIF11 (0.35) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL14529507 | 0.82 | KIF11 (0.46) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL17461286 | 0.82 | KIF11 (0.44) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL17461277 | 0.82 | KIF11 (0.48) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL14529520 | 0.82 | KIF11 (0.44) | KIF11KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL14020002 | 0.82 | KIF11 (0.44) | KIF11KDM4EMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761515-B1 | 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-11-05 | — | — | EP | disclosed |