Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020082 | 0.83 | KIF11 (0.47) | KIF11GAAKDM4EMEN1KMT2A | |
| SCHEMBL14020242 | 0.83 | KIF11 (0.47) | KIF11GAAKDM4EMEN1KMT2A | |
| SCHEMBL13923892 | 0.83 | KDM4E (0.44) | KIF11GAAARKDM4ELMNA | |
| SCHEMBL14020854 | 0.82 | KIF11 (0.40) | KIF11ARKDM4ELMNAHTT | |
| SCHEMBL14020845 | 0.82 | KIF11 (0.51) | KIF11ARKDM4ELMNAHTT | |
| SCHEMBL14020476 | 0.81 | KIF11 (0.33) | KIF11KDM4ELMNAHTTNPSR1 | |
| SCHEMBL14529833 | 0.80 | KIF11 (0.42) | KIF11GAAARKDM4ELMNA | |
| SCHEMBL13004938 | 0.79 | KIF11 (0.52) | KIF11GAAARKDM4ELMNA | |
| SCHEMBL14109441 | 0.78 | KIF11 (0.50) | KIF11GAAARKDM4ELMNA | |
| SCHEMBL14020880 | 0.73 | KIF11 (0.54) | KIF11GAAARKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761515-B1 | 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-11-05 | — | — | EP | disclosed |