SCHEMBL140205

SCHEMBL140205

CN1CCC(C(=O)Cl)CC1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
HTT P42858 1/20 0.39
LMNA P02545 1/20 0.38
HRH4 Q9H3N8 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
CYP1A2 P05177 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NCF1 P14598 1/20 0.36
HSD11B1 P28845 1/20 0.35
RIPK1 Q13546 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
SCN1A P35498 1/20 0.34
SCN2A Q99250 1/20 0.34
SCN3A Q9NY46 1/20 0.34
GNAI3 P08754 2/20 0.33
GNAO1 P09471 2/20 0.33
GNAI1 P63096 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL659109 0.98 ALDH1A1 (0.43) ALDH1A1HTTLMNAHRH4HRH3
Hydrochloric Acid SCHEMBL8126712 0.89 ALDH1A1 (0.50) ALDH1A1HTTLMNAMEN1KMT2A
SCHEMBL11454156 0.86
SCHEMBL27311104 0.79 ALDH1A1 (0.42) ALDH1A1HTTLMNAHRH4HRH3
SCHEMBL46774 0.77 ALDH1A1 (0.55) ALDH1A1HTTLMNA
SCHEMBL890089 0.77 CYP1A2 (0.44) ALDH1A1HTTLMNAHRH4HRH3
SCHEMBL16838100 0.77 HTT (0.45) ALDH1A1HTTLMNAHRH4HRH3
Hydrochloric Acid SCHEMBL29032347 0.77 ALDH1A1 (0.46) ALDH1A1HTTLMNAHRH4HRH3
SCHEMBL229158 0.76 CYP1A2 (0.44) CYP1A2TDP1SMN1; SMN2
SCHEMBL3947419 0.76 SMN1; SMN2 (0.47) SMN1; SMN2MEN1KMT2AGNAI3GNAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114144408-B Large scale preparation of 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide hemisuccinate and process and intermediates for preparing 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide acetate 伊莱利利公司 2025-04-15 CN claimed
EP-3996713-B1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE LILLY CO ELI (US) 2024-12-04 EP claimed
EP-4410784-A2 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE Eli Lilly and Company (US) 2024-08-07 EP claimed
US-20240059666-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY 2024-02-22 US claimed
US-11827618-B2 Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate ELI LILLY AND COMPANY 2023-11-28 US claimed
US-20230250076-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY 2023-08-10 US claimed
US-20230250075-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY 2023-08-10 US claimed
US-20230137090-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY 2023-05-04 US claimed
CN-114573555-A Preparation method of compound for treating migraine 上海天慈国际药业有限公司 2022-06-03 CN claimed
EP-3996713-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY (US) 2022-05-18 EP claimed
CN-114144408-A Process and intermediates for large scale preparation of 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide hemisuccinate and preparation of 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide acetate 伊莱利利公司 2022-03-04 CN claimed
WO-2021007155-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE ELI LILLY AND COMPANY (US) 2021-01-14 WO claimed
EP-2917212-B1 ANTIMICROBIAL AGENTS UNIV RUTGERS (US) 2019-06-12 EP claimed
CN-103408549-B A kind of preparation method of Lastacaft intermediate SUZHOU HUIHE PHARMACEUTICAL CO., LTD. (CN) 2016-01-20 CN claimed
CN-103408549-A Preparation method of alcaftadine intermediate SUZHOU HUIHE PHARM CO LTD 2013-11-27 CN claimed
CN-114573555-B Preparation method of compound for treating migraine 上海天慈国际药业有限公司 2026-02-17 CN disclosed
US-12528818-B2 Compositions and methods for inhibition of RAS LEIDOS BIOMEDICAL RESEARCH, INC. (US) 2026-01-20 US disclosed
US-4659707-A ANTIULCER, ANTISECRETORY, ANTIMUSCARINIC AND/OR ANTISPASMODIC AGENTS DOMPE' FARMACEUTICI S.P.A. (IT) 1987-04-21 US disclosed
EP-0213450-A2 Aminoacyl derivatives of 4,9-dihydro-10H-pyrido[3,2-b]-thieno-[3,2-e][1,4]diazepinone and of 4,9-dihydro-10H-pyrido[3,2-b]-thieno[3,4-e][1,4]diazepinone, their preparation and pharmaceutical compositions containing them DOMPE' FARMACEUTICI S.p.A. (IT) 1987-03-11 EP disclosed
US-4045445-A 11-(4-Piperidyl)dibenzo-diazepines AMERICAN CYANAMID COMPANY (US) 1977-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240059666-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE LPXN, KDM2A, PMP22 ALDH1A1 1176/4885HTT 202/4885LMNA 259/4885
US-20230250075-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE LPXN, KDM2A, PMP22 ALDH1A1 1176/4885HTT 202/4885LMNA 259/4885
US-11827618-B2 Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KDM4D, KDM5B ALDH1A1 1147/4885HTT 620/4885LMNA 479/4885
US-20230137090-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE LPXN, KDM2A, HTR2A ALDH1A1 1237/4885HTT 136/4885LMNA 408/4885
US-12528818-B2 Compositions and methods for inhibition of RAS KRAS, NRAS, HRAS ALDH1A1 2644/4885HTT 2171/4885LMNA 2939/4885
US-20230250076-A1 PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE LPXN, KDM2A, PMP22 ALDH1A1 1176/4885HTT 202/4885LMNA 259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.