Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | BCR | P11274 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 5/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021028 | 0.91 | PIK3CA (0.64) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021176 | 0.90 | ABL1 (0.55) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021032 | 0.88 | PDGFRA (0.62) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021033 | 0.87 | AURKA (0.62) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021027 | 0.87 | CAMK2D (0.67) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021038 | 0.87 | CAMK2D (0.71) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021025 | 0.86 | PDGFRA (0.58) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL4905540 | 0.86 | ABL1 (0.62) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021026 | 0.84 | PDGFRB (0.63) | ABL1BCRPDGFRAPDGFRBJAK2 | |
| SCHEMBL14021305 | 0.84 | CNR2 (0.51) | ABL1BCRJAK2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |