Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312590 | 0.86 | CDK1 (0.51) | KDRAURKAJAK2JAK3CDK1 | |
| SCHEMBL1512786 | 0.84 | PIK3CA (0.55) | AURKAJAK2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8312148 | 0.84 | CDK1 (0.62) | JAK2PIK3CAPIK3CBPIK3CGJAK3 | |
| SCHEMBL14021041 | 0.84 | ABL1 (0.57) | KDM4EMAPTJAK2PIK3CAPIK3CB | |
| SCHEMBL14021407 | 0.84 | JAK2 (0.51) | JAK2PIK3CAPIK3CBPIK3CGJAK3 | |
| SCHEMBL14063828 | 0.83 | CAMK2D (0.61) | JAK2PIK3CAPIK3CBPIK3CGJAK3 | |
| SCHEMBL14021219 | 0.83 | PIK3CA (0.58) | JAK2PIK3CAPIK3CBPIK3CGJAK3 | |
| SCHEMBL14063837 | 0.83 | CDK2 (0.52) | JAK2PIK3CAPIK3CBPIK3CGJAK3 | |
| SCHEMBL8312431 | 0.83 | RHOC (0.52) | CNR2KDM4EMAPTCNR1PIK3CA | |
| SCHEMBL8312575 | 0.82 | JAK2 (0.49) | JAK2PIK3CAPIK3CBPIK3CGJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |