Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | BCR | P11274 | 4/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021251 | 0.87 | JAK2 (0.57) | SLC6A7JAK2LMNAMAPTHTT | |
| SCHEMBL14021240 | 0.84 | HSP90AA1 (0.61) | SLC6A7JAK2MAPTHTTKMT2A | |
| SCHEMBL4385553 | 0.84 | JAK2 (0.72) | JAK2 | |
| SCHEMBL8312431 | 0.83 | RHOC (0.52) | ABL1BCRCNR1MAPT | |
| SCHEMBL8312954 | 0.82 | PIK3CA (0.52) | JAK2 | |
| SCHEMBL14063828 | 0.82 | CAMK2D (0.61) | SLC6A7JAK2KMT2AMEN1 | |
| SCHEMBL14021225 | 0.82 | JAK2 (0.60) | JAK2LMNASMN1; SMN2 | |
| SCHEMBL4376814 | 0.80 | JAK2 (0.72) | JAK2MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL14021219 | 0.80 | PIK3CA (0.58) | JAK2 | |
| SCHEMBL8311359 | 0.80 | PIK3CA (0.49) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |