Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | FABP3 | P05413 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340238 | 0.75 | PIM1 (0.43) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL14023023 | 0.66 | PDE5A (0.37) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL3338542 | 0.65 | KDM4E (0.41) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL3342615 | 0.63 | TP53 (0.43) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL3340787 | 0.63 | PDE5A (0.40) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL14023022 | 0.62 | PIM1 (0.55) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL386224 | 0.60 | PIM1 (0.67) | GCGRMAPK14PDE5APDE4APDE4B | |
| SCHEMBL19039959 | 0.60 | SIRT1 (0.47) | MGLLPTGER1ELANE | |
| SCHEMBL15094850 | 0.60 | ADRB2 (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10314842 | 0.60 | MEN1 (0.51) | HTR2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143759-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |