Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | POLR1A | O95602 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31288020 | 0.92 | RAB9A (0.64) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL18758193 | 0.88 | KMT2A (0.67) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL13211934 | 0.86 | KMT2A (1.00) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL11973926 | 0.86 | RAB9A (0.76) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL14817956 | 0.86 | KMT2A (0.76) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL10248313 | 0.85 | RAB9A (0.60) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL367407 | 0.84 | KMT2A (0.73) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL18740416 | 0.84 | RAB9A (0.61) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL18740419 | 0.84 | RAB9A (0.61) | RAB9AKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL18758129 | 0.83 | KMT2A (0.60) | RAB9AKMT2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015193229-A1 | BET-PROTEIN INHIBITING 1,4-DIHYDROPYRIDO[3,4-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-12-23 | — | — | WO | claimed |
| EP-2291359-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | AstraZeneca AB (SE) | 2011-03-09 | — | — | EP | claimed |
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | claimed |
| EP-2593437-B1 | MOLECULES HAVING COMBINABLE GROUPS | ARKEMA FRANCE (FR) | 2017-09-06 | — | — | EP | disclosed |
| WO-2017144393-A1 | 2-SUBSTITUTED 5-(PHENYL)-1,2-DIHYDRO-3H-3-BENZAZEPINE-3-CARBOXAMIDE DERIVATIVES AS BRD4 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-08-31 | — | — | WO | disclosed |
| EP-2291359-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | AstraZeneca AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |