Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934055 | 0.76 | DYRK1A (0.52) | DYRK1APDGFRBPDGFRAHTTKMT2A | |
| SCHEMBL29470857 | 0.76 | DYRK1A (0.52) | DYRK1APDGFRBPDGFRAHTTKMT2A | |
| SCHEMBL1574432 | 0.74 | DYRK1A (0.32) | DYRK1APDGFRBPDGFRA | |
| SCHEMBL1574430 | 0.74 | DYRK1A (0.32) | DYRK1APDGFRBPDGFRA | |
| SCHEMBL13768482 | 0.65 | CHRNB2 (0.35) | — | |
| SCHEMBL1574325 | 0.65 | DYRK1A (0.36) | DYRK1APDGFRBPDGFRAHTTKMT2A | |
| SCHEMBL12565427 | 0.64 | HTT (0.44) | DYRK1ARAB9AHTTKMT2A | |
| SCHEMBL29967332 | 0.64 | DYRK1A (0.38) | DYRK1AHTTKMT2A | |
| SCHEMBL30466588 | 0.63 | DYRK1A (0.41) | DYRK1APDGFRBPDGFRAHTTKMT2A | |
| SCHEMBL20386673 | 0.61 | DYRK1A (0.36) | DYRK1AHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456196-B2 | Bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2008-11-25 | — | — | US | disclosed |