Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27265275 | 0.86 | KDM4E (0.44) | LMNAKDM4EHTTTHRBFYN | |
| SCHEMBL11865948 | 0.81 | L3MBTL1 (0.42) | HTTTHRBADORA2AHSP90AA1SMN1; SMN2 | |
| SCHEMBL6623077 | 0.81 | LMNA (0.46) | LMNAKDM4EHTTTHRBSMN1; SMN2 | |
| SCHEMBL16134092 | 0.79 | LMNA (0.40) | LMNAKDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL6619029 | 0.78 | NPC1 (0.44) | LMNAKDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL3965244 | 0.78 | LMNA (0.39) | LMNAKDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL1521589 | 0.78 | HTT (0.51) | LMNAKDM4EHTTTHRBSMN1; SMN2 | |
| SCHEMBL30346051 | 0.78 | LMNA (0.39) | LMNAKDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL29541506 | 0.78 | LMNA (0.39) | LMNAKDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL1521534 | 0.78 | LMNA (0.39) | LMNAKDM4EHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449472-B2 | Methods of inhibiting p38 with substituted bicyclic pyrimidines | ROCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7439247-B2 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | ROCHE PALO ALTOP LLC (US) | 2008-10-21 | — | — | US | disclosed |