Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.53 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.53 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791622 | 0.91 | POLB (0.62) | POLBHPGDALOX15TDP1CYP1A2 | |
| SCHEMBL7138929 | 0.85 | CYP1A2 (0.52) | POLBHPGDALOX15TDP1CYP1A2 | |
| SCHEMBL8149664 | 0.83 | PRSS1 (0.73) | ALDH1A1SMN1; SMN2PRSS1TPSAB1TPSD1 | |
| SCHEMBL30576720 | 0.82 | PRSS1 (0.71) | ALDH1A1SMN1; SMN2PRSS1TPSAB1TPSD1 | |
| SCHEMBL160429 | 0.80 | KCNA5 (0.67) | HPGDALOX15TDP1CYP1A2ALDH1A1 | |
| SCHEMBL4197525 | 0.79 | CHRM2 (0.58) | POLBHPGDALOX15TDP1CYP1A2 | |
| SCHEMBL31550495 | 0.79 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2PRSS1TPSAB1TPSD1 | |
| SCHEMBL7143650 | 0.79 | CYP1A2 (0.57) | POLBCYP1A2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7401301 | 0.78 | NPC1 (0.67) | POLBHPGDALOX15TDP1ALDH1A1 | |
| SCHEMBL8178335 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2PRSS1TPSAB1TPSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | CCR5, CCL2, CXCR4 | POLB 2589/4885HPGD 247/4885ALOX15 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.