Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23928899 | 0.81 | HTT (0.45) | BRD4PTGER4TTRALBHTT | |
| SCHEMBL29880693 | 0.81 | PTGER4 (0.43) | PTGER4HTTTP53HPGDSGRM5 | |
| SCHEMBL31020829 | 0.81 | HTT (0.45) | BRD4PTGER4TTRALBHTT | |
| SCHEMBL23452230 | 0.81 | PTGER4 (0.43) | PTGER4HTTTP53HPGDSGRM5 | |
| SCHEMBL28960178 | 0.81 | PTGER4 (0.40) | BRD4PTGER4TTRALBHTT | |
| SCHEMBL27765124 | 0.79 | PTGER4 (0.42) | PTGER4HTTTP53HPGDSGRM5 | |
| SCHEMBL17211632 | 0.76 | BRD4 (0.55) | BRD4HASPINKDM4E | |
| SCHEMBL25230123 | 0.76 | RORC (0.46) | PTGER4RORC | |
| SCHEMBL24331224 | 0.75 | BRD4 (0.50) | BRD4HASPINGSK3B | |
| SCHEMBL22554076 | 0.75 | BRD4 (0.50) | BRD4HASPINGSK3BCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |