Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23452230 | 0.79 | PTGER4 (0.43) | PTGER4ALDH1A1TP53HPGDSHTT | |
| SCHEMBL31020829 | 0.79 | HTT (0.45) | PTGER4ALDH1A1TP53HPGDSHTT | |
| SCHEMBL14031125 | 0.79 | BRD4 (0.47) | PTGER4ALDH1A1TP53HPGDSHTT | |
| SCHEMBL23928899 | 0.79 | HTT (0.45) | PTGER4ALDH1A1TP53HPGDSHTT | |
| SCHEMBL29880693 | 0.79 | PTGER4 (0.43) | PTGER4ALDH1A1TP53HPGDSHTT | |
| SCHEMBL25230123 | 0.75 | RORC (0.46) | PTGER4RORC | |
| SCHEMBL14031024 | 0.71 | IMPDH2 (0.47) | PTGER4ALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL27072911 | 0.68 | GRM5 (0.61) | PTGER4HPGDSHTTIRAK4DYRK1A | |
| SCHEMBL904725 | 0.66 | HPGDS (0.43) | PTGER4ALDH1A1HPGDSIRAK4GRM5 | |
| SCHEMBL27439703 | 0.65 | DYRK1A (0.59) | DYRK1AKDM4EMETPIM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103497188-A | Compounds modulating c-fms and/or c-kit activity and uses therefor | PLEXXIKON INC | 2014-01-08 | — | — | CN | disclosed |
| CN-101605787-B | Compounds that modulate c-fms and/or c-kit activity and uses thereof | PLEXXIKON INC | 2013-11-13 | — | — | CN | disclosed |
| CN-101605787-A | Compounds that modulate c-fms and/or c-kit activity and uses thereof | PLEXXIKON INC (US) | 2009-12-16 | — | — | CN | disclosed |