Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.84 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.84 |
| ▸ | CNR2 | P34972 | 1/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.79 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | PTGES | O14684 | 1/20 | 0.79 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | ALB | P02768 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.79 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11092811 | 0.92 | PTGS2 (0.88) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL30426824 | 0.92 | PTGS2 (1.00) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL14086813 | 0.92 | PTGS2 (1.00) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL4549122 | 0.90 | PTGS2 (1.00) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL28817657 | 0.90 | PTGS2 (0.84) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL2238173 | 0.89 | PTGS2 (1.00) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL29855593 | 0.89 | PTGS2 (0.86) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL12988768 | 0.89 | PTGS2 (0.86) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10788764 | 0.89 | PTGS2 (0.83) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL8978311 | 0.89 | PTGS2 (0.86) | PTGS2AKR1C3CNR2PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261913-A1 | Phosphoroamidate conjugated to therapeutic agent such as Aclarubicin; nucleoside derivatives; S-pivaloyl-2-thioethyl phosphoroamidate; liver cancer, inflammation, fibrosis, metabolic disorders | IDENIX PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261913-A1 | Phosphoroamidate conjugated to therapeutic agent such as Aclarubicin; nucleoside derivatives; S-pivaloyl-2-thioethyl phosphoroamidate; liver cancer, inflammation, fibrosis, metabolic disorders | NTPCR, PNP, TYMP | PTGS2 4118/4885AKR1C3 1657/4885CNR2 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.