Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | INSRR | P14616 | 1/20 | 0.41 |
| ▸ | FECH | P22830 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14031987 | 0.91 | IGF1R (0.46) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031642 | 0.91 | IGF1R (0.44) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031649 | 0.90 | IGF1R (0.42) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL401368 | 0.89 | IGF1R (0.59) | IGF1RCYP3A4TNK2INSRKDR | |
| SCHEMBL14031798 | 0.88 | TNK2 (0.56) | IGF1RCYP3A4TNK2INSRKDR | |
| SCHEMBL14031809 | 0.87 | IGF1R (0.44) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031647 | 0.85 | GRIN2B (0.45) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031806 | 0.85 | IGF1R (0.46) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031991 | 0.82 | IGF1R (0.47) | IGF1RCYP3A4INSRKDRMAPK3 | |
| SCHEMBL14031988 | 0.82 | IGF1R (0.44) | IGF1RCYP3A4INSRKDRMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080267957-A1 | Combination cancer therapy | IGF1R, IGFBP4, IGFBP1 | IGF1R 1/4885CYP3A4 1844/4885TNK2 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.