Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033981 | 0.83 | SCN4A (0.39) | LTA4HRIPK1CYP2D6MEN1KMT2A | |
| SCHEMBL14033384 | 0.83 | CYP17A1 (0.51) | LTA4HSRD5A2LMNAMAPTCYP2D6 | |
| SCHEMBL14622082 | 0.81 | PDK2 (0.37) | LTA4HRIPK1MEN1KMT2APDK2 | |
| SCHEMBL11420513 | 0.80 | LTA4H (0.57) | LTA4HSRD5A2LMNACYP2D6MEN1 | |
| SCHEMBL677488 | 0.79 | KCNA3 (0.50) | LTA4HRIPK1LMNACYP2D6PDK2 | |
| SCHEMBL13141341 | 0.77 | NQO1 (0.48) | LTA4HMAPTMEN1KMT2APDK2 | |
| SCHEMBL14366325 | 0.77 | LTA4H (0.62) | LTA4HSRD5A2LMNATAAR1 | |
| SCHEMBL18287924 | 0.77 | ELANE (0.49) | LTA4HELANERIPK1SRD5A2 | |
| SCHEMBL7267685 | 0.76 | LTA4H (0.57) | LTA4HSRD5A2LMNAMAPTCYP2D6 | |
| SCHEMBL7462021 | 0.76 | NPC1 (0.51) | LTA4HLMNAMAPTHPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |