Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17861696 | 0.84 | GPR88 (0.48) | LTA4HGPR88MAPTRAB9AALDH1A1 | |
| SCHEMBL14366325 | 0.84 | LTA4H (0.62) | LTA4HALDH1A1PKMSRD5A2LMNA | |
| SCHEMBL7273071 | 0.83 | GPR88 (0.44) | LTA4HGPR88MAPTRAB9AALDH1A1 | |
| SCHEMBL18682251 | 0.82 | MAPT (0.44) | LTA4HMAPTRECQL | |
| SCHEMBL2949666 | 0.81 | FFAR1 (0.62) | GPR88MAPTRAB9AALDH1A1NPSR1 | |
| SCHEMBL8472309 | 0.81 | LTA4H (0.59) | LTA4HMAPTALDH1A1NPSR1PKM | |
| SCHEMBL11420513 | 0.80 | LTA4H (0.57) | LTA4HBRD4CREBBPALDH1A1GAA | |
| SCHEMBL31003208 | 0.80 | ACACB (0.43) | GPR88MAPTRECQLCYP2D6 | |
| SCHEMBL8476224 | 0.80 | LTA4H (0.63) | LTA4HMAPTRAB9AALDH1A1LMNA | |
| SCHEMBL17100113 | 0.80 | LTA4H (0.39) | LTA4HBRD4CREBBPMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935414-A | New indolylpropanols, processes for their preparation and their use, and preparations containing the compounds | BEIERSDORF AG (DE) | 1990-06-19 | — | — | US | disclosed |
| EP-0297380-A2 | Indolyl propanols, process for their preparation, their uses and preparation containing them | Beiersdorf-Lilly GmbH (DE) | 1989-01-04 | — | — | EP | disclosed |