Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279576 | 0.84 | MAPK1 (0.62) | MAPK1SMN1; SMN2KMT2APTPN1CA2 | |
| SCHEMBL216185 | 0.82 | PTPN1 (0.62) | MAPK1SMN1; SMN2MEN1KMT2APTPN1 | |
| SCHEMBL1976973 | 0.80 | PTPN1 (0.60) | MAPK1SMN1; SMN2MEN1KMT2APTPN1 | |
| SCHEMBL28665290 | 0.80 | PTPN1 (0.60) | MAPK1SMN1; SMN2MEN1KMT2APTPN1 | |
| SCHEMBL3378865 | 0.79 | SMN1; SMN2 (0.60) | MAPK1SMN1; SMN2PTPN1CA2PTPN11 | |
| SCHEMBL4724618 | 0.79 | SMN1; SMN2 (0.70) | LMNAHPGDMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL7433625 | 0.79 | MAPK1 (0.60) | MAPK1SMN1; SMN2PTPN1CA2PTPN11 | |
| SCHEMBL27867721 | 0.79 | HPGD (0.67) | LMNAHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17941569 | 0.77 | MAPK1 (0.72) | MAPK1SMN1; SMN2PTPN1CA2PTPN11 | |
| SCHEMBL11706791 | 0.77 | HPGD (0.70) | LMNAHPGDMEN1KMT2AITGA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |