Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 6/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216185 | 0.98 | PTPN1 (0.62) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL28665290 | 0.96 | PTPN1 (0.60) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| Trifluoromethanesulfonamide SCHEMBL4288876 | 0.90 | CA2 (0.62) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL19042259 | 0.85 | CA2 (0.49) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL17266478 | 0.84 | PTPN1 (0.49) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL18048059 | 0.82 | PTPN1 (0.51) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL6001500 | 0.81 | PTPN1 (0.86) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL28027003 | 0.81 | PTPN1 (0.54) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL14033372 | 0.80 | LMNA (0.59) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL4972432 | 0.79 | PTGS1 (0.70) | CA2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404693-B2 | Substituted piperidine compounds and methods of their use | ADOLOR CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-20110144108-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144108-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND METHODS OF THEIR USE | OPRM1, OPRK1, OPRD1 | PTPN1 3263/4885CA2 3989/4885PTPN11 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.