Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 4/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17694697 | 0.81 | KDM4E (0.51) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL8446905 | 0.80 | ALDH1A1 (0.49) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL4483861 | 0.80 | BACE1 (0.61) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL8446966 | 0.78 | ALDH1A1 (0.52) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL4472383 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL15591268 | 0.76 | KDM4E (0.50) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL9152375 | 0.76 | CA4 (0.68) | KDM4EALDH1A1BACE1LMNANPSR1 | |
| SCHEMBL17283658 | 0.76 | CA4 (0.68) | KDM4EALDH1A1BACE1LMNANPSR1 | |
| SCHEMBL291776 | 0.76 | CA4 (0.68) | KDM4EALDH1A1BACE1LMNANPSR1 | |
| Biphenyl SCHEMBL11784329 | 0.76 | CA4 (0.68) | KDM4EALDH1A1BACE1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287424-A1 | AZOLYLACYLGUANIDINES AS beta-SECRETASE INHIBITORS | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287424-A1 | AZOLYLACYLGUANIDINES AS beta-SECRETASE INHIBITORS | BACE1, BACE2, APP | GRIK2 596/4885GRIK1 643/4885KDM4E 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.