Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082754 | 0.78 | ALDH1A1 (0.52) | BRD4ALDH1A1MAPTKDM4EKCNH2 | |
| SCHEMBL4020226 | 0.78 | LRRK2 (0.46) | BRD4ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL17978520 | 0.77 | DDX3X (0.52) | NR4A1ALDH1A1MAPTKCNH2GAA | |
| SCHEMBL4093222 | 0.76 | MAPT (0.47) | BRD4MAPTNOTUMSNCA | |
| SCHEMBL14036564 | 0.76 | SNCA (0.53) | BRD4ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL20283634 | 0.75 | KDM4E (0.49) | NR4A1BRD4ALDH1A1MAPTKDM4E | |
| SCHEMBL16896842 | 0.74 | NR4A1 (0.70) | NR4A1BRD4ALDH1A1MAPTKDM4E | |
| SCHEMBL1039243 | 0.74 | NR4A1 (0.51) | NR4A1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL511425 | 0.73 | NR4A1 (0.54) | NR4A1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL511511 | 0.73 | NR4A1 (0.54) | NR4A1KCNH2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |