Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 9/20 | 0.46 |
| ▸ | BCHE | P06276 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240603 | 0.81 | LMNA (0.46) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL11449732 | 0.78 | LMNA (0.54) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL10145748 | 0.78 | LMNA (0.42) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL12535558 | 0.76 | LMNA (0.52) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL9685093 | 0.76 | PTGS1 (0.55) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL14036619 | 0.76 | LMNA (0.52) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL14227856 | 0.76 | LMNA (0.52) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL1762784 | 0.76 | LMNA (0.52) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL20353850 | 0.76 | LMNA (0.47) | LMNATRPA1PTGS1CACNA1CACHE | |
| SCHEMBL13948898 | 0.75 | TAAR1 (0.52) | SLC6A4SLC6A2KCNH2HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749355-B1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE (\"NACK\") AND METHODS FOR USE OF THE SAME | UNIV MIAMI (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |