Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917026 | 0.94 | LMNA (0.41) | CYP3A4TSHRMAPK1LMNATP53 | |
| SCHEMBL9493682 | 0.92 | LMNA (0.39) | CYP3A4TSHRMAPK1LMNATP53 | |
| SCHEMBL1753957 | 0.80 | KDM4E (0.46) | CYP3A4TSHRMAPK1LMNATP53 | |
| SCHEMBL754453 | 0.80 | CYP3A4 (0.41) | CYP3A4TSHRMAPK1CYP1A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10782102 | 0.78 | CYP3A4 (0.39) | CYP3A4TSHRMAPK1CYP1A2ALDH1A1 | |
| SCHEMBL14378407 | 0.77 | PDE2A (0.47) | CYP3A4LMNATP53HTTCYP1A2 | |
| SCHEMBL1754168 | 0.77 | POLB (0.47) | CYP2D6 | |
| SCHEMBL20969672 | 0.77 | POLB (0.47) | CYP2D6 | |
| SCHEMBL1753939 | 0.77 | POLB (0.47) | CYP2D6 | |
| SCHEMBL4972071 | 0.77 | LMNA (0.39) | CYP3A4TSHRMAPK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412660-B1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | EA PHARMA CO LTD (JP) | 2020-11-18 | — | — | EP | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |